Monogenic Diabetes
What the clinician should know

Comprehensive Guide on Monogenic Diabetes

ABOUT the BOOK

Monogenic diabetes, a rare form of diabetes resulting from a single gene mutation, presents unique challenges and opportunities in clinical practice. This book, “Monogenic Diabetes: What the clinician should know” by Drs. V. Mohan, Ranjit Unnikrishnan, and Radha Venkatesan, offers a comprehensive and current exploration of monogenic diabetes, emphasizing precision medicine for diabetes and in its diagnosis and treatment.

A detailed examination of the various types of monogenic diabetes, including their genetic etiology, clinical features, diagnostic strategies, and therapeutic approaches, is presented with clarity and depth. The book also includes an insightful section on the practical aspects of managing monogenic diabetes, which will provide invaluable guidance for endocrinologists. Overall, this book is an essential resource for physicians, endocrinologists and diabetologists, geneticists, and postgraduate and undergraduate students, offering a valuable tool for the effective diagnosis and management of monogenic diabetes in clinical practice. It will be a valuable addition to any library.

A unique publication on the rare genetic forms of monogenic diabetes

Comprehensive overview of the genetic basis, clinical presentation, and management strategies

Incorporates the latest international references, current evidence-based practices and global clinical guidelines

FEATURES OF THE BOOK

TABLE OF CONTENTS

• Understanding Monogenic Diabetes
• Genetic basis of Monogenic Diabetes
• Classification of Monogenic Diabetes

Section 1:

Monogenic Diabetes: Introduction

Section 3:

Clinical Guidelines and Recommendations

Section 5:

Case Studies and Patient Stories

Section 2:

Monogenic Diabetes: Clinical Aspects

• Maturity-onset Diabetes of the Young (MODY)
• Neonatal Diabetes Mellitus
• Genetic Syndromes Associated with Neonatal Diabetes

• Wolcott-Rallison Syndrome (WRS)
• IPEX syndrome
• Wolfram syndrome
• Thiamine-responsive megaloblastic anemia syndrome (TRMA)

• Congenital Hyperinsulinism of Infancy
• Mitochondrial Diabetes

• Maternally inherited diabetes with deafness (MIDD)
• Other mitochondrial disorders predisposingto diabetes

• Mitochondrial encephalopathy with lactic acidosisand stroke-like episodes (MELAS)
• Kearns-Sayre syndrome (KSS)
• Mitochondrial neurogastrointestinal encephalopathy(MNGIE)
• Pearson syndrome
• Chronic progressive external ophthalmoplegia withmyopathy (CPEO+)
• Myoclonic epilepsy with ragged-red fibres (MERRF)
• Leber hereditary optic neuropathy (LHON)

Section 4:

Diagnosis and Management of Monogenic Diabetes: A Practical Guide

Section 6:

Future Research in this Field

Section 7:

Key highlights

Section 8:

A Recent and novel discovery of a MODY subtype

Index:

MD, FRCP (London, Edinburgh, Glasgow, Ireland), PhD, DSc (Hon. Causa), FNASc, FASc, FNA, FACE, FTWAS, MACP, FRS (Edinburgh)

Chairman & Chief Diabetologist, Dr. Mohan’s Diabetes Specialities Centre & Director, Madras Diabetes Research Foundation, Chennai

Dr. V. Mohan

MD, FRCP (London, Glasgow & Edinburgh), FACE, FACP, FICP

Vice-Chairman and Consultant Diabetologist Dr. Mohan’s Diabetes Specialities Centre, Chennai

Dr. Ranjit Unnikrishnan

ABOUT THE AUTHORS

MSc, PhD.

Executive Scientific Officer and Head, Molecular Genetics Department, Madras Diabetes Research Foundation, Chennai

Dr. Radha Venkatesan